The Presence Of Rat Model Of Parkinson s Disease Induced...

The present study was established to show revealed the presence of neurochemical and histopathological changes in the cerebellum of rat model of Parkinson’s disease induced by the intrastriatal injection of rotenone. This may change the strategy of the disease treatment that depends mainly on the restoration of dopamine levels in the basal ganglia. The present findings showed the development of hyperexcitability in the cerebellum of rat model of PD induced by intrastriatal injection of rotenone. This was indicated from the significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate and the significant decrease in the inhibitory amino acids; GABA, glycine and taurine. These neurotransmitters are involved in many functions such as motor behavior, cognition, and emotion (Ottersen and Storm-Mathisen, 1986, Schmidt et al., 1992)1,2. The balance between excitatory and inhibitory neurotransmission is important for brain to sustain proper neuronal function (Mel et al., 2004)[1]. Perturbation in glutamatergic and GABAergic neurotransmission is associated with several neurological and psychiatric disorders (Sanacora et al., 2004) (3) [glutamate gaba balance 1]. Functional neuroimaging study using PET or blood oxygen level-dependent functional MRI frequently demonstrated increased activation in the cerebellum in patients with PD during performance of various upper limb movements (Rascol et al., 1997; Catalan et al., 1999; Wu and Hallett, 2005; Yu etShow MoreRelatedThe Presence Of Rat Model Of Parkinson s Disease Induced By The Intrastriatal Injection Of Rotenone Essay1309 Words   |  6 PagesThe present study revealed the presence of neurochemical and histopathological changes in the cerebellum of rat model of Parkinson’s disease induced by the intrastriatal injection of rotenone. This may change the strategy of the disease treatment that depends mainly on the restoration of dopamine levels in the basal ganglia. The present findings showed the development of hyperexcitability in the cerebellum of rat model of PD induced by intrastriatal injection of rotenone. This was indicated from the The Presence Of Rat Model Of Parkinson s Disease Induced... The present study revealed the presence of neurochemical and histopathological changes in the cerebellum of rat model of Parkinson’s disease induced by the intrastriatal injection of rotenone. This may change the strategy of the disease treatment that depends mainly on the restoration of dopamine levels in the basal ganglia. The present findings showed the development of hyperexcitability in the cerebellum of rat model of PD induced by intrastriatal injection of rotenone. This was indicated from the significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate and the significant decrease in the inhibitory amino acids; GABA, glycine and taurine. These neurotransmitters are involved in many functions such as motor behavior, cognition, and emotion (Ottersen and Storm-Mathisen, 1986, Schmidt et al., 1992)1,2. The balance between excitatory and inhibitory neurotransmission is important for brain to sustain proper neuronal function (Mel et al., 2004)[1]. Perturbation in glutamatergic and GABAergic neurotransmission is associated with several neurological and psychiatric disorders (Sanacora et al., 2004) (3) [glutamate gaba balance 1]. Functional neuroimaging study using PET or blood oxygen level-dependent functional MRI frequently demonstrated increased activation in the cerebellum in patients with PD during performance of various upper limb movements (Rascol et al., 1997; Catalan et al., 1999; Wu and Hallett, 2005; Yu et al., 2007; Wu et al.,Show MoreRelatedThe Presence Of Rat Model Of Parkinson s Disease Induced By The Intrastriatal Injection Of Rotenone1107 Words   |  5 Pagesestablished to show revealed the presence of neurochemical and histopathological changes in the cerebellum of rat model of Parkinson’s disease induced by the intrastriatal injection of rotenone. This may change the strategy of the disease treatment that depends mainly on the restoration of dopamine levels in the basal ganglia. The present findings showed the development of hyperexcitability in the cerebellum of rat model of PD induced by intrastriatal injection of rotenone. This was indicated from the